EPISODE · Mar 1, 2026 · 20 MIN
749. 视觉成像揭示肺癌药物重塑蛋白机制
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金泽大学的研究人员利用高速原子力显微镜技术，首次实时观测到肺癌致癌蛋白 EML4-ALK 的动态结构变化。研究发现，靶向药物不仅能抑制酶的活性，还能物理性地重塑蛋白质结构，从而阻止其形成诱发癌症的聚集体。然而，当蛋白质发生特定的耐药突变时，这种结构重塑效应会消失，揭示了治疗失效的分子机制。这一发现为开发针对蛋白质动态特性的新一代抗癌疗法提供了科学依据。该研究强调了单分子成像技术在理解复杂生物过程及应对药物有效性差异方面的重要价值。内容来源：https://phys.org/news/2026-01-visualizing-cancer-drugs-reshape-proteins.html
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749. 视觉成像揭示肺癌药物重塑蛋白机制
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