EPISODE · Apr 6, 2026 · 23 MIN
752-工程化活胶水治疗炎症性肠病
from 聊聊Sci
这篇研究介绍了一种名为治疗性活胶（TL-glue）的工程化大肠杆菌，用于精准治疗炎症性肠病（IBD）。这种工程菌集成了血液感应、生物黏附与原位治疗三大模块，能够通过优化后的基因电路高灵敏度地识别肠道出血信号。一旦感应到出血，细菌便会分泌源自藤壶的黏附蛋白，使其能牢固附着在受损组织表面长达数日，并持续释放修复因子TFF3。在小鼠模型实验中，该系统显著缓解了肠道炎症，促进了黏膜修复并减少了出血。这项技术克服了传统活菌药物在肠道内难以定位和长期留存的难题，为下一代智能化生物药物的开发提供了新思路。References: Ge C, Jiang S, Dong X, et al. Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease[J]. Nature Biotechnology, 2026: 1-11.前往小宇宙评论区与主播互动
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