EPISODE · Apr 8, 2026 · 26 MIN
761-卵巢癌空间肿瘤演化的多组学全景图
from 聊聊Sci
这项发表于《细胞报告医学》（Cell Reports Medicine）的研究通过整合全基因组测序、单细胞转录组及空间转录组技术，系统揭示了高等级浆液性卵巢癌的多位点转移演变全景。研究者开发了名为 STARLETS 的追踪系统，发现肿瘤克隆在缺氧和免疫压力的双重筛选下，演化出具有更强转移能力的克隆并向腹腔扩散。研究鉴定出一个由 SPP1+ 巨噬细胞、MMP11+ 成纤维细胞与恶性上皮细胞构成的“三元合奏”结构，该结构在腹水和转移灶中促进肿瘤扩散。实验证明，靶向 SPP1-CD44 信号轴能有效瓦解这种转移单元并抑制癌细胞迁徙。此外，SPP1+ 巨噬细胞的丰度被证实可作为预测溶瘤病毒和 PARP 抑制剂疗效的重要指标。该成果为理解卵巢癌的空间动态演化提供了新视角，并为精准治疗提供了潜在靶点。References: Feng C, Yang Y, Li G, et al. Spatial tumor evolution panorama of ovarian cancer[J]. Cell Reports Medicine, 2026, 7(3).前往小宇宙评论区与主播互动
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