EPISODE · Apr 8, 2026 · 15 MIN
763-Maf与Jun调控原始造血中小胶质细胞的发育
from 聊聊Sci
这项研究揭示了控制小胶质细胞和组织驻留巨噬细胞发育的独特遗传机制。研究发现，虽然转录抑制因子 Zeb2 对所有巨噬细胞的形成都至关重要，但不同发育阶段的细胞依赖不同的增强子来驱动其表达。在原始造血过程中，转录因子 Maf 和 Jun 共同作用，独立于特定的 -165 kb 增强子来激活 Zeb2，从而推动小胶质细胞的产生。相比之下，来自定型造血（如成年骨髓）的单核细胞和巨噬细胞则必须依赖该增强子才能发育。实验表明，缺乏 Maf 的胚胎会出现严重的小胶质细胞发育缺陷。这一发现明确了区分大脑小胶质细胞与其他免疫细胞谱系的转录调控网络。References: Chen J, Du S, Cheng W, et al. Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis[J]. Immunity, 2026, 59(1): 48-59. e5.前往小宇宙评论区与主播互动
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763-Maf与Jun调控原始造血中小胶质细胞的发育
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