766-全脑原位Perturb-seq哺乳动物功能基因组图谱

这份研究介绍了一个利用增强型 in vivo Perturb-seq 技术构建的全小鼠大脑基因功能图谱。研究人员通过对 74 只小鼠的大脑进行高通量筛选，分析了 1,947 个与疾病相关的基因在 770 万个单细胞核中的表达反应。实验结果揭示了基因在不同神经元类型中具有特异性的生存必要性，并展现了复杂的转录调控网络。研究特别发现，像 Grin2a 和 Grin2b 这样相似的致病基因在相同细胞中竟会触发截然相反的转录程序。此外，该图谱证实了神经发育障碍（NDD）等人类疾病基因的效应会富集在特定的神经回路中。总而言之，这项工作为在大脑原生环境中理解遗传风险与细胞功能之间的联系奠定了坚实基础。References:* Shi T, Korshunova M, Kim S, et al. Genome-scale functional mapping of the mammalian who...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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