77. Is Depression Evolutionary? with Dr Charles Raison

Is depression evolutionary? Is inflammation good or bad? Can sleep be bad for you? Tune in to find out.  Depression is a complex and debilitating mental health disorder that affects millions of people worldwide. Despite the prevalence of depression, its causes and origins are still not entirely understood. In this episode of the Drug Science Podcast, we explore the evolutionary perspective on depression with renowned psychiatrist and researcher, Dr. Charles Raison. Dr. Charles Raison is a psychiatrist and professor at the University of Wisconsin-Madison and Emory University. Having moved from the field of anthropology into psychiatry, Dr. Raison is now internationally recognized for his studies examining novel mechanisms involved in the development and treatment of major depression and other stress-related emotional and physical conditions, as well as for his work examining the physical and behavioral effects of compassion training.   The New Mind-Body Science of DepressionAndrew H. Miller  Interferon alphaParoxetine for the prevention of depression induced by high-dose interferon alfaInfliximab Tumor necrosis factorA randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkersAntidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorderBurning down the house: reinventing drug discovery in psychiatry for the development of targeted therapies CRP Interleukin 6 (IL-6)Interleukin 1 betaWim HofPivotal mental statesUsona InstituteCOMPASS PathwaysCentre for Psychedelics and Spirituality Psilocybin MAPSMDMATrial of Psilocybin versus Escitalopram for Depression5-MeO-DMTSleeping with one eye open: loneliness and sleep quality in young adults ★ Support this podcast ★