EPISODE · Apr 10, 2026 · 17 MIN
771-泛癌视角下双阴性T细胞单细胞图谱与功能多样性研究
from 聊聊Sci
这份研究通过整合来自23种癌症类型的单细胞转录组数据，构建了迄今为止最全面的双阴性T细胞（DNT）全癌种单细胞图谱。研究团队鉴定出14个具有独特功能和临床意义的DNT亚群，涵盖了具有免疫调节功能的αβ DNT和具备强细胞毒性及抗原呈递能力的γδ T细胞。通过空间转录组和功能实验，研究揭示了特定亚群（如T14_HLA-DR+）在增强抗肿瘤免疫和预测免疫治疗响应中的关键作用。此外，研究还发现了肠道驻留DNT细胞在肿瘤环境下的功能可塑性，从抗癌状态向促癌状态转变的过程。总体而言，该成果阐明了DNT细胞的异质性及其在肿瘤微环境中的复杂角色，为开发下一代个性化癌症免疫疗法提供了重要理论依据。References: Hao Q, Zhou T, Yan H, et al. A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells[J]. Molecular Cancer, 2026.前往小宇宙评论区与主播互动
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771-泛癌视角下双阴性T细胞单细胞图谱与功能多样性研究
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