EPISODE · Apr 11, 2026 · 19 MIN
777-多样化生物样本库助力精准医疗研究
from 聊聊Sci
UCLA ATLAS 社区健康倡议通过整合 92,164 名参与者的电子健康记录与基因数据，构建了一个极具祖源多样性的生物库。研究涵盖了 5 个大洲层级和 36 个细分层级的祖源群体，揭示了不同族群在疾病患病率和遗传风险上的显著差异。通过全表型关联研究（PheWAS）和全外显子组关联研究（ExWAS），科学家发现了多个此前未报道的祖源特异性风险位点。此外，该研究利用纵向临床数据，证实了遗传因素对司美格鲁肽（Semaglutide）减重效果的影响。这项成果克服了以往研究中严重的欧洲裔数据偏见，为推进更公平、更精准的个性化医疗提供了关键见解。该生物库的深度和广度展示了在多元化医疗系统中开展精准健康研究的巨大潜力。References: Haas R, Margolis M P, Wei A, et al. Advancing Precision Health Discovery in a Genetically Diverse Health System[J]. medRxiv, 2025: 2025.06. 11.25329386.前往小宇宙评论区与主播互动
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777-多样化生物样本库助力精准医疗研究
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