EPISODE · Apr 11, 2026 · 13 MIN
779-肠道微生物代谢物烟酸驱动结肠区域化与损伤保护
from 聊聊Sci
这项研究揭示了肠道微生物群通过分泌代谢产物（特别是烟酸），在确立大肠不同区域的细胞身份中起着决定性作用。实验证明，结肠细胞的区域化特征并非源于干细胞的内在遗传，而是受到微生物信号的外部驱动。通过激活PPARα通路，微生物产生的烟酸能诱导结肠近端细胞形成特定的基因表达模式，从而增强组织对损伤的抵抗力。此外，研究还发现这种微生物调控的区域特征在克罗恩病患者中会发生缺失，揭示了肠道健康与区域平衡之间的紧密联系。References: Rispal J, Garcia J R, Palikuqi B, et al. Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility[J]. Cell, 2026.前往小宇宙评论区与主播互动
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779-肠道微生物代谢物烟酸驱动结肠区域化与损伤保护
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