79: Clinical trial reporting (with Henry Drysdale)

We chat with Henry Drysdale (University of Oxford), co-founder of the COMPare trials project, which compared clinical trial registrations with reported outcomes in five top medical journals and qualitatively analysed the responses to critical correspondence. Discussion points and links galore: The history behind the COMPare project The two papers that were published: a prospective cohort study correcting and monitoring 58 misreported trials and a qualitative analysis of researchers’ responses to critical correspondence Ben Goldacre's books What is outcome switching? What were some of the responses to query letters from the authors and journals? Misreporting trials (usually) doesn't lead to patient harm, but it harms the evidence base Where should the buck stop with outcome switching? Would Registered Reports solve this problem? The CONSORT guidelines Have the journals changed their practices? COMPare on twitter The COMPare website Here is Henry on Twitter - @HenryMDrysdale Here is Ben Goldacre on Twitter - @bengoldacre Other links [Dan on twitter](www.twitter.com/dsquintana) [James on twitter](www.twitter.com/jamesheathers) [Everything Hertz on twitter](www.twitter.com/hertzpodcast) [Everything Hertz on Facebook](www.facebook.com/everythinghertzpodcast/) Music credits: [Lee Rosevere](freemusicarchive.org/music/Lee_Rosevere/) Support us on Patreon and get bonus stuff! $1 a month or more: Monthly newsletter + Access to behind-the-scenes photos & video via the Patreon app + the the warm feeling you're supporting the show $5 a month or more: All the stuff you get in the $1 tier PLUS a bonus mini episode every month (extras + the bits we couldn't include in our regular episodes) Episode citation and permanent link Quintana, D.S., Heathers, J.A.J. (Hosts). (2019, March 4) "Clinical trial reporting (with Henry Drysdale)", Everything Hertz [Audio podcast], doi: 10.17605/OSF.IO/HBX8RSpecial Guest: Henry Drysdale.