790-小鼠全身分子与细胞图谱研究

这份研究介绍了一种针对实验室小鼠的全身体空间转录组测序及细胞图谱绘制平台。通过结合Array-seq技术与计算机算法，研究人员成功在六周龄小鼠的全身切片上精确标注了379种细胞类型以及各器官的组织结构。此外，团队开发了名为LABEL的机器学习模型，能够仅凭传统的H&E染色影像实现自动化的组织与细胞注释。该技术被应用于研究内毒素血症引发的全身性炎症，揭示了不同器官在疾病状态下复杂的基因表达变化与细胞间通讯。这项工作为在分子和细胞层面开展系统生物学研究及药物靶点探索提供了强大的工具。References: Clevenger M H, Cipurko D, Patil A, et al. Whole-body molecular and cellular mapping of the laboratory mouse[J]. Cell, 2026.前往小宇宙评论区与主播互动

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790-小鼠全身分子与细胞图谱研究

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