EPISODE · Apr 14, 2026 · 18 MIN
791-uPAR阳性肿瘤生态系统：CAR T细胞疗法的广谱靶点
from 聊聊Sci
这项发表于2026年《Cell》杂志的研究揭示了uPAR（尿激酶型纤溶酶原激活物受体）在实体瘤治疗中的核心价值。研究发现，uPAR在携带TP53或RAS突变的高侵袭性肿瘤中广泛表达，且标记了肿瘤内部由衰老基质细胞构成的促纤维化及免疫抑制微环境。uPAR CAR T细胞在多种临床前模型中表现出卓越功效，能够同步清除恶性肿瘤细胞及其支撑性的基质结构。这种疗法不仅能有效杀伤原发灶与全身转移瘤，且在人源化模型中未产生显著的骨髓毒性。此外，联合化疗等诱导细胞衰老的手段可显著上调uPAR表达，进而增强CAR T细胞的清除能力。总之，该研究证明了以uPAR为靶点的细胞疗法能突破实体瘤的物理与免疫屏障，为跨癌种治疗提供了新策略。References: Zhang Z, Ho Y J, Fang X, et al. A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy[J]. Cell, 2026.前往小宇宙评论区与主播互动
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791-uPAR阳性肿瘤生态系统：CAR T细胞疗法的广谱靶点
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