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May 31, 2026 25 min

80. I'm a Dead Man Walking

from The ManuScript with Manu Edakkara Hosted by the.manuscript

We cover the biology of pancreatic cancer and why it's one of the most lethal diagnoses in medicine, what stage 4 actually means, and where the science is headed with KRAS inhibitors, BRCA2 targeted therapies, and clinical trials. Then we go deeper into something I think most people avoid: the moment you're born is the moment you start dying. Telomere biology, cellular senescence, Heidegger's "beings-toward-death," memento mori, mono no aware, Buddhist impermanence, and Irvin Yalom's awakening experiences. And finally, what all of this means for how we actually live; Bronnie Ware's regrets of the dying, the Blue Zones research on longevity and belonging, Maslow on self-actualization, Viktor Frankl on meaning, and Seneca on time. We are all dead men walking. The only real question is what we do with the time. Regrets of the dying: https://open.spotify.com/episode/07Y5iqmIoOvSgI8kR4hLMV Blue Zones: https://open.spotify.com/episode/7zTJuHOlfzue7PTsZ0u1xK Self-Actualization: https://open.spotify.com/episode/2JjRwLjNm8w6U7krHLkDb3 93-Year-Old's Advice on Life: https://open.spotify.com/episode/0Vf7rlzQzGIbgQoqRyktIr Find Your Purpose: https://open.spotify.com/episode/6gP7Jhy88sL87qWQl3TuFL

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80. I'm a Dead Man Walking

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This episode was published on May 31, 2026.

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