EPISODE · Apr 16, 2026 · 19 MIN
805-小胶质细胞与胶质母细胞瘤在远端浸润区的交互作用
from 聊聊Sci
这项研究利用先进的三光子活体显微镜技术，深入探索了胶质母细胞瘤（GB）在小鼠大脑深层区域——远端浸润区的扩散机制。研究发现，肿瘤细胞的迁移速度与其肿瘤微管的数量呈负相关，且在胼胝体等白质结构中表现出更强的侵袭性。作为大脑的常驻免疫细胞，小胶质细胞对肿瘤的入侵呈现出双相反应：在早期稀疏浸润时加强监测，而在肿瘤密集后受到抑制。通过对CX3CR1受体缺失或CSF1R抑制剂诱导的小胶质细胞耗竭进行观察，证实了小胶质细胞在调节肿瘤迁移及微管塑性中起着关键支撑作用。这些发现揭示了胶质母细胞瘤与免疫微环境之间复杂的空间异质性交互，为遏制肿瘤复发提供了新的潜在治疗靶点。References: Nebeling F C, Fuhrmann F, Mittag M, et al. Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone[J]. Immunity, 2026.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
805-小胶质细胞与胶质母细胞瘤在远端浸润区的交互作用
0:00
19:12
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 19 minutes long.
When was this 聊聊Sci episode published?
This episode was published on April 16, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!