809-单细胞四组学测序解析基因调控图谱

这篇发表于2026年的研究论文介绍了一种名为CHARM的新型单细胞四组学测序技术，旨在深入解析基因组的调控图谱。该技术实现了在同一个单细胞内，同时对染色质构象、组蛋白修饰、染色质可及性及基因表达进行并行检测。研究人员通过对小鼠胚胎干细胞和大脑皮层组织的应用，成功重建了集成化的表观基因组配置。这些数据揭示了细胞周期中表观遗传信息的动态变化，以及调控元件在三维核空间中的空间聚合特征。此外，利用可解释的机器学习模型，该研究精准识别了数千个增强子与启动子的连接，阐明了它们如何以细胞类型特异性的方式驱动基因表达。总之，CHARM为在复杂组织中解码三维基因组的多层级调控机制提供了一个功能强大的技术平台。References:* Chen Y, Liu Z, Xu H, et al. Gene regulatory landscape dissected by single-cell four-om...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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