EPISODE · Apr 18, 2026 · 23 MIN
817-AhR 抑制通过触发“应激-生长转换”促进轴突再生
from 聊聊Sci
这份研究揭示了芳香烃受体（AhR）在哺乳动物神经再生中发挥着关键的“刹车”作用。研究发现，虽然神经损伤会诱发 AhR 激活以维持细胞的蛋白质稳态并应对压力，但这种机制同时抑制了轴突的生长。通过基因敲除或药物抑制手段阻断 AhR 信号，可以将神经元的反应模式从压力适应转变为积极生长状态。实验证明，抑制 AhR 能显著增强外周神经和脊髓损伤后的轴突再生，并加速功能恢复。此外，该过程涉及 AhR 与 HIF1α 等因子之间的代谢信号竞争与协同。总之，靶向 AhR 为开发促进中枢神经系统修复的治疗方案提供了新的理论依据。References: Halawani D, Wang Y, Li J, et al. AhR inhibition promotes axon regeneration via a stress–growth switch[J]. Nature, 2026: 1-11.前往小宇宙评论区与主播互动
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817-AhR 抑制通过触发“应激-生长转换”促进轴突再生
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