819-结肠炎的表观遗传记忆促进肿瘤生长

这份研究探讨了慢性炎症如何通过表皮干细胞的“表观遗传记忆”诱发癌症。研究人员利用小鼠肠炎模型发现，即使炎症消退百日之后，结肠干细胞仍会保留异常的染色质可及性和DNA甲基化记录。这种记忆主要受AP-1转录因子驱动，使细胞处于一种预激发的增殖状态。通过新开发的SHARE-TRACE技术，研究证实这种病理记忆能在细胞分裂中克隆遗传。最终，这些携带记忆的干细胞在面对致癌突变时，会展现出更强的成瘤能力，揭示了环境暴露转化为长期癌症风险的分子机制。References: Nagaraja S, Ojeda-Miron L, Zhang R, et al. Epigenetic memory of colitis promotes tumour growth[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动

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819-结肠炎的表观遗传记忆促进肿瘤生长

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