EPISODE · Apr 20, 2026 · 19 MIN
822-Perturb-seq识别活体心脏重编程的关键障碍Calr
from 聊聊Sci
这项发表在《Cell Stem Cell》上的研究通过Perturb-seq技术，系统性地筛查了心肌梗死后阻碍心脏直接重编程的分子屏障。研究人员在活体小鼠模型中对比了140个候选基因，确认钙网蛋白（Calr）是抑制成纤维细胞转化为心肌细胞的核心障碍。在受损心脏中，Calr的表达显著升高，通过限制胞质钙离子浓度来抑制关键转录因子MEF2C的活性。实验证明，敲低Calr能有效激活钙信号通路，显著提升原位心肌再生的效率并改善心脏功能。这一发现为心脏损伤后的再生治疗提供了全新的分子靶点和理论框架。References: Cai Y, Yang Y, Yang J, et al. Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo[J]. Cell Stem Cell, 2026.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
822-Perturb-seq识别活体心脏重编程的关键障碍Calr
0:00
19:21
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 19 minutes long.
When was this 聊聊Sci episode published?
This episode was published on April 20, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!