825-乳腺癌转移中的三维形态发生蓝图

这篇文章揭示了乳腺癌远处转移的一种关键机制，即癌细胞会重新激活一种名为转移性小梁形态发生（MTM）的胚胎发育程序。研究发现，乳腺癌的大转移灶并非随机生长，而是模仿胎儿乳腺导管的分支发育模式，构建出一种由上皮细胞组成的3D晶格结构。这种独特的空间架构受控于ETV1/4/5等核心转录因子，它们对转移瘤的形成至关重要，但对原发瘤的生长并非必不可少。具有这种分支结构倾向的原发肿瘤细胞在早期就表现出更强的侵袭性，且与患者的预后不良密切相关。此外，研究确定了FGF-FGFR信号通路是维持该结构的关键弱点，这为针对致命性的癌症转移阶段开发新疗法提供了理论依据。References:* Caire R, Bordo R, Zanconato F, et al. A 3D morphogenetic blueprint for metastatic outgrowth in breast cancer[...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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825-乳腺癌转移中的三维形态发生蓝图

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