EPISODE · Apr 20, 2026 · 17 MIN
830-小细胞肺癌原发与淋巴结转移灶的单细胞空间转录组图谱
from 聊聊Sci
这项研究通过单细胞空间转录组技术，系统地绘制了小细胞肺癌（SCLC）从原发灶到淋巴结转移灶的空间细胞图谱。研究人员识别出三种与转移密切相关的恶性细胞亚群，这些亚群展现出独特的代谢程序与空间免疫排斥特征。通过分析细胞间的空间组织，研究揭示了血管与免疫细胞之间的动态交互，以及内皮细胞如何通过重塑微环境来驱动免疫激活。此外，研究定义了一个名为PIHs-1的泛免疫热点，其丰度被证实是预测患者生存预后的独立指标。这些发现不仅阐明了小细胞肺癌在转移过程中的微环境异质性，也为临床转化和新药研发提供了潜在的生物标志物。References: Zhang Z, Wu D, Chen R, et al. Single-cell spatial transcriptomics reveals tumor microenvironment heterogeneity in primary and lymph node-metastatic small cell lung cancer[J]. Cell Reports Medicine, 2026.前往小宇宙评论区与主播互动
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830-小细胞肺癌原发与淋巴结转移灶的单细胞空间转录组图谱
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