EPISODE · Apr 22, 2026 · 19 MIN
839-巴马香猪围产期大脑发育时空多组学图谱
from 聊聊Sci
这份研究通过对巴马猪围产期大脑的转录组与蛋白质组进行深度测序，构建了首个大动物多组学动态发育图谱。研究发现，猪的大脑发育在分子层面与人类高度相似，能够精准填补人类胚胎后期到婴儿早期研究的数据空白。分析揭示了在妊娠末期存在一个关键的发育拐点，此时突触生成与胶质细胞成熟发生剧烈变化。此外，研究证实猪脑中疾病风险基因的表达模式会随发育向成年状态过渡。该成果为解析神经发育障碍的致病机制提供了一个强有力的跨物种转化研究框架。References: Wang Z, Chu F, Wang X, et al. Perinatal brain developmental transition revealed by transcriptomic and proteomic analyses of Bama miniature pigs[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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