EPISODE · Apr 23, 2026 · 17 MIN
842-噬菌体入侵诱导的亚细胞重组与病毒组装机制
from 聊聊Sci
这项研究利用冷冻电子断层扫描技术，揭示了SPP1噬菌体在感染枯草芽孢杆菌后，如何通过重塑宿主细胞结构来协调病毒颗粒的组装。研究发现，感染会导致细胞内形成一个不含核糖体的病毒DNA区室，且病毒结构的初步构建始于细胞内膜上的前体。在门户蛋白gp6的引导下，初步组装的前衣壳会迁移至病毒DNA区室，随后在基因组封装过程中经历结构扩张。最终，充满DNA的衣壳移动到区室边缘，与预先组装好的尾部结合，形成完整的成熟病毒。这一发现揭示了噬菌体增殖过程在空间和时间上的高度有序性，为理解病毒与宿主相互作用提供了新的分子机制。References: Corroyer-Dulmont S, Labarde A, Pražák V, et al. Subcellular reorganization upon phage infection reveals stepwise assembly of viral particles from membrane-associated precursors[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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842-噬菌体入侵诱导的亚细胞重组与病毒组装机制
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