EPISODE · Apr 24, 2026 · 23 MIN
846-scHiCAR：复杂组织单细胞转录、表观及三维基因组三模态图谱研究
from 聊聊Sci
本文介绍了一种名为 scHiCAR 的多模态单细胞测序新技术，旨在同时捕捉单细胞中的转录组、表观基因组和三维基因组信息。该方法利用板式组合条形码技术，能够高效且低成本地分析数百万个细胞，尤其擅长捕捉与顺式调节元件（CREs）相关的长距离染色质相互作用。研究人员将此技术应用于小鼠大脑及骨骼肌等复杂组织，成功绘制了高分辨率的基因调节图谱。为了辅助数据分析，团队还开发了基于深度的学习算法 scDeepLUCIA，即使在细胞数量较少的情况下也能精准识别染色质环。总之，scHiCAR 为研究复杂组织中细胞异质性及其基因表达的结构调控提供了强有力的工具。References: Wei X, Xu Y, Yang D, et al. Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR[J]. Nature biotechnology, 2026: 1-16.前往小宇宙评论区与主播互动
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846-scHiCAR：复杂组织单细胞转录、表观及三维基因组三模态图谱研究
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