EPISODE · Apr 25, 2026 · 18 MIN
852-通过逆流键工程攻克肿瘤自抗原T细胞耐受
from 聊聊Sci
这项研究介绍了一种名为“TCR涡轮增压”的新型免疫工程平台，旨在通过捕捉键（catch-bond）工程技术增强T细胞对癌症的杀伤力。研究人员针对前列腺癌中的前列腺酸性磷酸酶（PAP），成功改良了原本反应微弱的天然T细胞受体。通过在受体特定区域引入关键的氨基酸突变，这种技术延长了受体与肿瘤抗原结合的有效时间，从而在不增加脱靶风险的前提下，显著提升了T细胞在体内的增殖能力和抗肿瘤活性。实验结果显示，这种经工程化改良的T细胞能更有效地清除肿瘤，并展现出更强的抵抗免疫疲劳的特性。该成果为开发更高效、更安全的TCR-T细胞疗法提供了一种基于生物物理机制的新策略。References: Chen X, Mao Z, Kolawole E M, et al. Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering[J]. Science, 2026, 391(6791): eadx3162.前往小宇宙评论区与主播互动
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852-通过逆流键工程攻克肿瘤自抗原T细胞耐受
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