853-Architectural Secrets of the Mouse Cytoplasmic Lattice

This research paper describes the atomistic-resolution structure of the mouse cytoplasmic lattice (CPL), a massive protein storage organelle essential for mammalian reproduction. Using single-particle cryo-electron microscopy, scientists determined that the CPL is a 4-MDa repeating unit featuring a tripartite architecture of an external framework, linkers, and a core. The study reveals how this lattice sequesters and inhibits vital maternal factors, such as the epigenetic regulator UHRF1, GTP-bound tubulin, and ubiquitin ligase components. These stored proteins are held in a poised but inactive state to ensure their timely release during the critical oocyte-to-embryo transition. By providing a molecular blueprint of the CPL, the authors establish a framework for diagnosing and treating female infertility caused by genetic defects. Mapping over 300 clinical variants onto this structure further confirms that lattice integrity is indispensable for early embryonic development.References: Chi P, Wang X, Li J, et al. Structure of the mouse cytoplasmic lattice[J]. Nature, 2026: 1-3.前往小宇宙评论区与主播互动