863-人类产前发育整合单细胞与空间组学图谱

该研究通过整合现有数据与新生成的单细胞和空间转录组学数据，构建了名为“人类发育细胞图谱 (HDCA)”的综合资源，详细描绘了人类产前发育过程。该图谱涵盖了从受孕后第4周到第22周的约460万个细胞，精细划分为450多种细胞类型。通过对6周龄完整胚胎进行114个组织微环境（Niches）的无监督深度学习分析，研究者揭示了成纤维细胞祖细胞的区域化分布、心脑血管系统早期器官特异性的形成，以及外周神经系统复杂的谱系演变。此外，该研究还开发了名为Cherita的在线交互平台，将细胞图谱与先天性发育疾病基因相连接，为理解人类早期生长机制及临床病理提供了重要的参考坐标系。References: Webb S, Rose A, Xu C, et al. An integrated single cell and spatial omics atlas of human prenatal development[J]. bioRxiv, 2026: 2026.03. 30.714220.前往小宇宙评论区与主播互动

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863-人类产前发育整合单细胞与空间组学图谱

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