EPISODE · Apr 27, 2026 · 17 MIN
865-Protenix-v2：跨越结构预测与生物分子设计的建模系统
from 聊聊Sci
Protenix-v2 是一种由 ByteDance Seed 开发的前沿生物分子建模系统，涵盖了高精度的结构预测与分子设计功能。在结构预测方面，该模型显著提升了抗体-抗原界面的模拟准确性，其仅用 5 个种子的采样效率便超越了前代模型 1000 个种子的表现。在设计领域，它实现了对 GPCR 等最具挑战性的药物靶点的零点射击（zero-shot）发现，并保持了极高的命中率、多样性和可开发性。此外，该系统通过引入训练辅助引导（TFG）增强了小分子配体的化学合理性，并成功设计出能同时结合多种新冠病毒变体的广谱结合剂。这些成果共同确立了 Protenix-v2 作为加速药物研发及理解生物相互作用的强大工具地位。References: doi: https://doi.org/10.64898/2026.04.10.717613前往小宇宙评论区与主播互动
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865-Protenix-v2：跨越结构预测与生物分子设计的建模系统
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