EPISODE · Apr 28, 2026 · 17 MIN
868-pH依赖性转录凝聚体对炎症反应的调节
from 聊聊Sci
这项研究揭示了巨噬细胞如何通过感知胞内pH值的变化来精准调节炎症反应。研究发现，酸性环境会通过一种基因特异性的方式重塑炎症程序，其中BRD4蛋白被鉴定为关键的pH传感器。在生理pH条件下，BRD4通过其富含组氨酸的内在无序区（IDR）形成转录凝聚体以激活基因；而环境酸化会导致组氨酸质子化，进而瓦解这些凝聚体。这种机制不仅在染色体建模和增强子激活中起核心作用，还作为一种负反馈调节，平衡免疫保护与组织损伤。总之，该发现证明了转录凝聚体能将环境信号直接整合进基因表达，为理解炎症的自我校准提供了新视角。References: Wu Z, Pope S D, Ahmed N S, et al. Regulation of inflammatory responses by pH-dependent transcriptional condensates[J]. Cell, 2025, 188(20): 5632-5652. e25.前往小宇宙评论区与主播互动
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