EPISODE · Apr 29, 2026 · 18 MIN
872-人母胎界面单细胞时空图谱
from 聊聊Sci
这份研究通过整合单细胞多组学与高空间分辨率转录组技术，构建了涵盖孕早期至足月的人类母胎界面空间细胞图谱。作者详尽描绘了胎儿胎盘细胞与母亲子宫组织间的复杂相互作用，并提出了调节滋养细胞分化的“双稳态切换模型”。研究重点解析了螺旋动脉重塑过程中的血管内皮细胞状态转变，并识别出能抑制滋养细胞侵袭的特定子宫内膜基质细胞亚型。此外，该图谱将分子特征与遗传数据关联，精准定位了与先兆子痫和早产等妊娠并发症相关的易感细胞。这一成果为理解人类胎盘发育的正常机制及其病理障碍提供了关键的空间多维参考。References: Wang C, Zhou Y, Wang Y, et al. Single-cell spatiotemporal dissection of the human maternal–fetal interface[J]. Nature, 2026: 1-13.前往小宇宙评论区与主播互动
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