873-小鼠皮层发育的多模态调控景观

该研究利用多模态单细胞测序技术，深入解析了小鼠大脑新皮层发育过程中的基因调控网络。研究人员整合了转录组、染色质开放性、DNA甲基化及三维基因组架构等多维度数据，成功识别出数千个具有细胞类型特异性的增强子及其目标基因。通过在体大规模平行报告实验（MPRA），他们证实了这些调控元件的功能，并揭示了转录因子（如Neurog2）在协调表观遗传重塑中的核心作用。研究结果表明，转录因子不仅能驱动增强子活性，还能介导DNA去甲基化和染色质环的形成，从而精准调控神经细胞的身份构建。这项工作为理解大脑发育的分子逻辑提供了全面的路线图，并强调了多层调控机制在谱系分化中的协同重要性。References:* Noack F, Vangelisti S, Raffl G, et al. Multimodal profiling of the transcriptional regulatory landsca...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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873-小鼠皮层发育的多模态调控景观

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