EPISODE · Apr 30, 2026 · 20 MIN
876-NeMO Analytics: 神经发育转录组数据探索平台
from 聊聊Sci
NeMO Analytics 是一个专为神经科学研究设计的转录组数据整合与分析平台，旨在解决公共领域多组学数据碎片化和处理复杂的问题。该平台汇集了来自约200项研究的新皮层发育及体外模型数据，涵盖人类、猕猴和小鼠等多个物种。通过应用联合矩阵分解（SJD）算法，研究人员能够识别跨物种保守的基因表达动态，并精确追踪神经发生的分子演变。研究揭示了外径向胶质细胞（oRG）在灵长类演化过程中的独特程序，同时也发现体外类器官模型在模拟神经元成熟方面存在一定局限。该资源通过直观的可视化界面，邀请无需编程背景的细胞生物学家共同参与新皮层发育的探索与数据贡献。References: Sonthalia S, Herb B, Adkins R S, et al. NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development[J]. Nature Neuroscience, 2026: 1-14.前往小宇宙评论区与主播互动
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