EPISODE · Apr 30, 2026 · 18 MIN
879-肿瘤劫持巨噬细胞补铁促进骨转移与贫血
from 聊聊Sci
这项研究揭示了癌细胞如何通过劫持骨髓中的巨噬细胞来获取铁元素，从而促进骨转移并引发贫血。在正常生理状态下，骨髓中的红细胞岛巨噬细胞负责为红细胞生成提供必要的铁，但癌细胞会改变这些细胞的分布，使其聚集在肿瘤周围。通过夺取红细胞所需的铁供应，肿瘤不仅支持了自身的快速生长和对缺氧环境的适应，还严重干扰了正常的红细胞成熟和脱核过程。这种竞争机制导致了红细胞生成障碍，解释了癌症骨转移患者普遍出现贫血的分子基础。该发现为针对肿瘤微环境中的铁代谢干预提供了新的治疗思路。References: Han Y, Sarkar H, Xu Z, et al. Tumors hijack macrophages for iron supply to promote bone metastasis and anemia[J]. Cell, 2025, 188(22): 6335-6354. e26.前往小宇宙评论区与主播互动
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879-肿瘤劫持巨噬细胞补铁促进骨转移与贫血
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