88. Progesterone and Brain Health: Debunking the Cognitive Decline Myth | HRT University® episode artwork

EPISODE · Mar 9, 2026 · 40 MIN

88. Progesterone and Brain Health: Debunking the Cognitive Decline Myth | HRT University®

from The HRT University® Podcast · host Nico Misleh

Is oral progesterone harmful to brain health?Recently, claims have circulated suggesting that progesterone may contribute to cognitive decline or act similarly to benzodiazepines because of its metabolite allopregnanolone. In this episode, Nico Misleh breaks down the science behind these claims and explains why much of the concern comes from misinterpreted research.This conversation explores the role of progesterone in hormone replacement therapy, the difference between animal studies and human evidence, and why understanding hormone physiology is essential for both providers and patients.If you are navigating hormone therapy or want a clearer understanding of progesterone’s role in cognitive health, this episode offers an evidence-based perspective on one of the most misunderstood hormones in medicine.For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University:https:https://bit.ly/4twBb0D- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

Is oral progesterone harmful to brain health?Recently, claims have circulated suggesting that progesterone may contribute to cognitive decline or act similarly to benzodiazepines because of its metabolite allopregnanolone. In this episode, Nico Misleh breaks down the science behind these claims and explains why much of the concern comes from misinterpreted research.This conversation explores the role of progesterone in hormone replacement therapy, the difference between animal studies and human evidence, and why understanding hormone physiology is essential for both providers and patients.If you are navigating hormone therapy or want a clearer understanding of progesterone’s role in cognitive health, this episode offers an evidence-based perspective on one of the most misunderstood hormones in medicine.For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University:https:https://bit.ly/4twBb0D- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

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88. Progesterone and Brain Health: Debunking the Cognitive Decline Myth | HRT University®

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This episode was published on March 9, 2026.

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Is oral progesterone harmful to brain health?Recently, claims have circulated suggesting that progesterone may contribute to cognitive decline or act similarly to benzodiazepines because of its metabolite allopregnanolone. In this episode, Nico...

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