EPISODE · May 1, 2026 · 21 MIN
884-双重神经群体驱动的大脑血容量波动
from 聊聊Sci
这项研究揭示了小鼠脑血流量波动的神经机制，否定了仅靠单一“批量神经活动”预测血供的传统观点。研究人员结合功能超声成像（fUSI）和Neuropixels记录发现，大脑中普遍存在两类功能对立的神经元群体：Arousal+（随觉醒增强）和Arousal–（随觉醒减弱）。这两类神经元拥有截然不同的血流动力学响应函数，且共同分布于全脑所有区域。通过整合这两类群体的活动，科学家能够精准预测从睡眠到活跃等不同觉醒状态下的血供变化。这一发现解释了为何不同脑区的血流量波动看似存在差异，实则遵循统一的神经血管耦合规律。这项工作为理解大脑如何在不同状态下调节能量供应提供了全新的理论框架。References: Landemard A, Krumin M, Harris K D, et al. Brainwide blood volume reflects opposing neural populations[J]. Nature, 2026: 1-9.前往小宇宙评论区与主播互动
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884-双重神经群体驱动的大脑血容量波动
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