EPISODE · May 2, 2026 · 23 MIN
888-脑血管腔面蛋白质组学及其屏障调节因子研究
from 聊聊Sci
这项研究开发并验证了一种在体蛋白质组学制图方法，能够精准锁定脊椎动物血管系统的管腔表面蛋白。通过向小鼠及树鼩血管灌注凝集素偶联过氧化物酶，研究者实现了对血脑屏障调节因子的动态捕捉，并绘制了涵盖发育、成年至衰老全生命周期的脑血管表面蛋白质图谱。定量质谱分析揭示了随着年龄增长，血管在代谢交换、炎症信号及机械适应方面的显著分子演变。此外，研究通过原位遗传筛选确定了SLC7A1与HYAL2等关键蛋白在维持不同年龄阶段血脑屏障完整性中的核心作用。这一技术不仅深化了对神经血管生物学的理解，也为研究其他器官的血管生理与病理提供了强有力的通用工具。References: Zhu Z, Jiang Z, Wang Y, et al. Luminal surface proteome of the brain vasculature uncovers blood-brain barrier regulators[J]. Science, 2026, 392(6794): eaea2100.前往小宇宙评论区与主播互动
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888-脑血管腔面蛋白质组学及其屏障调节因子研究
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