EPISODE · May 2, 2026 · 26 MIN
889-MitoCatch：细胞类型靶向线粒体移植系统
from 聊聊Sci
这项研究开发了一种名为 MitoCatch 的创新系统，旨在通过蛋白质结合技术实现线粒体向特定受损细胞的精准移植。该系统利用单特异性或双特异性结合剂作为“桥梁”，使健康的供体线粒体能够有效地与目标细胞表面结合并被其内吞。实验证明，这些外源线粒体进入细胞后能成功逃逸至胞质，并保持运动、分裂与融合等生物活性。研究人员在人类神经元、心血管细胞以及离体人类视网膜等多种模型中验证了该技术的有效性。最终，这种定向移植方案成功挽救了因线粒体功能障碍而受损的神经元，为治疗视神经萎缩和心力衰竭等目前尚无良方的疾病提供了新的医疗策略。References: Ayupov T, Moreno-Juan V, Curtoni S, et al. Cell-type-targeted mitochondrial transplantation rescues cell degeneration[J]. Nature, 2026: 1-11.前往小宇宙评论区与主播互动
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889-MitoCatch：细胞类型靶向线粒体移植系统
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