EPISODE · May 3, 2026 · 16 MIN
893-衰老小鼠大脑单细胞空间转录组图谱
from 聊聊Sci
这篇源自《Cell》的研究通过结合单细胞转录组成像与测序技术，构建了小鼠大脑额叶皮层和纹状体随年龄变化的高分辨率细胞图谱。研究发现，相比于神经元，非神经元细胞（如胶质细胞和免疫细胞）在衰老过程中表现出更显著的基因表达与空间分布变化。特别是大脑白质区域成为了炎症反应的聚集地，其中少突胶质细胞的激活与周边免疫细胞的状态密切相关。此外，科研人员对比了自然衰老与系统性炎症诱发的脑部反应，揭示了两者在细胞激活模式上的共性与独特差异。这些发现为理解大脑功能随年龄增长而衰退的分子机制提供了关键见解。References: Allen W E, Blosser T R, Sullivan Z A, et al. Molecular and spatial signatures of mouse brain aging at single-cell resolution[J]. Cell, 2023, 186(1): 194-208. e18.前往小宇宙评论区与主播互动
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