EPISODE · May 4, 2026 · 19 MIN
898-钙信号驱动的神经元膜骨架动态重塑研究
from 聊聊Sci
这项研究揭示了神经元中膜相关周期性骨架（MPS）并非此前认为的稳定结构，而是具有动态重塑的特性。研究利用活细胞超分辨率成像技术发现，即使在无外部刺激的情况下，MPS 也会经历不断的局部拆解与重建。这种动态过程主要由钙离子信号驱动：钙离子流入激活了 PKC 激酶以解稳肌动蛋白环，同时激活了钙蛋白酶来降解分 spectrin 蛋白。此外，这种骨架的重塑受神经元活动的增强，并能有效促进轴突内的胞吞作用。该发现改写了人们对神经元细胞骨架稳定性的认知，强调了其在维持膜可塑性和信号调节中的关键作用。References:Heller E, Kurup N, Zhuang X. The membrane skeleton is constitutively remodeled in neurons by calcium signaling[J]. Science, 2025, 389(6760): eadn6712.前往小宇宙评论区与主播互动
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898-钙信号驱动的神经元膜骨架动态重塑研究
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