9 15 2025

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Aficamten or Metoprolol Monotherapy for Obstructive Hypertrophic Cardiomyopathy

Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

Multidomain Rehabilitation for Older Patients with Myocardial Infarction

  Journal of  American Medical Association

Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis

The PRIME Diagnostic Clinical Trial

  Annals of Internal Medicine

Exposure to CT and Pregnancy Outcomes

  British Medical Journal

Second cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016 

 Lancet

Benefit–harm trade-offs of intensive blood pressure control versus standard blood pressure control on cardiovascular and renal outcomes: an individual participant data analysis of randomised controlled trials

JAMA oncology 

Debt, Bankruptcy, and Credit Scores After Cancer Diagnosis

  Journal of Clinical Rheumatology 

Pilot Study: Development and Evaluation of Validity Evidence of a Low-Cost, Low-Fidelity Hand Model to Teach Clinical Assessment of Small Joint Swelling in Inflammatory Arthritis

  Journals of the American College of Cardiology

Trajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease

 JAMA Cardiology

Polygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events

  Journal of Clinical Endocrinology & Metabolism

YAP1 Is a Prognostic Marker and Its Inhibition Reduces Tumor Progression in Adrenocortical Tumors

 Diabetes care

Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Emergency Department Visits and Hospitalization in Patients With Chronic Kidney Disease 

  Neurology

Association of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors

   Chest

Association of Timely Spirometry With Lower All-Cause Mortality

 Risk Factors for Patient-Important Upper Gastrointestinal Bleeding 

Clinical Journal of American Society of Nephrology

Pregnancy and Long-Term Kidney Function in CKD: A Systematic Review and Meta-Analysis

 Kidney International reports

Meta-Analysis of Randomized Controlled Trials on Gamma-Aminobutyric Acid Analogues and Opioid-Based Therapies for CKD-Associated Pruritus

A Systematic Review of Sleep Hygiene Strategy in CKD