9 22 2025

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes

Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity

Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation

  Journal of  American Medical Association

Prediction of Platelet Transfusion Outcomes in Preterm Infants With Severe Thrombocytopenia

  Annals of Internal Medicine

The Cost-Effectiveness of Semaglutide and Tirzepatide for Patients With Knee Osteoarthritis and Obesity

 British Medical Journal

Second cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016

 Lancet

Paclitaxel-coated versus uncoated devices for infrainguinal endovascular revascularisation in patients with intermittent claudication (SWEDEPAD 2): a multicentre, participant-masked, registry-based, randomised controlled trial

  JAMA oncology 

Established Cancer Predisposition Genes in Single and Multiple Cancer Diagnoses

Falls Among Individuals With Systemic Lupus Erythematosus: An Observational Study

Journals of the American College of Cardiology

Safety and Effectiveness of Statins for Primary Prevention in Adults With Type 1 Diabetes: An Emulation

  JAMA Cardiology

One-Year Outcomes of Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST ElevationAn Individual Patient Data Meta-Analysis

 Journal of Clinical Endocrinology & Metabolism

Association Between Urinary Phthalate Metabolites and Sarcopenia in US Adults From NHANES 2011-2018

 Diabetes care

A Multimodal Predictive Model for Chronic Kidney Disease and Its Association With Vascular Complications in Patients With Type 2 Diabetes: Model Development and Validation Study in South Korea and the U.K. 

  Neurology

Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging

  Chest

Investigating the Long-Term Effects of COVID-19 Infection on Health Care Utilization in Individuals With COPD

 The American Journal of Respiratory and Critical Care Medicine

Molecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation

 Clinical Journal of American Society of Nephrology

Sodium-Glucose Cotransporter 2 Inhibition and Hospitalizations in Patients with CKD: A Meta-Analysis of Kidney Outcome Trials

Kidney International reports

Prospective Pilot Study of Plasma Cell–Targeted Therapy With Bortezomib in Refractory IgA Nephropathy

Community-Acquired Acute Kidney Injury and Late Kidney Dysfunction in Survivors of COVID-19 Hospitalization