9 22 2025

Hi, This Week in Medicine, we will be discussingFirst we will be discussing articles in New England Journal of Medicine Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 DiabetesOral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation  Journal of  American Medical AssociationPrediction of Platelet Transfusion Outcomes in Preterm Infants With Severe Thrombocytopenia  Annals of Internal MedicineThe Cost-Effectiveness of Semaglutide and Tirzepatide for Patients With Knee Osteoarthritis and Obesity British Medical JournalSecond cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016 LancetPaclitaxel-coated versus uncoated devices for infrainguinal endovascular revascularisation in patients with intermittent claudication (SWEDEPAD 2): a multicentre, participant-masked, registry-based, randomised controlled trial  JAMA oncology Established Cancer Predisposition Genes in Single and Multiple Cancer DiagnosesFalls Among Individuals With Systemic Lupus Erythematosus: An Observational StudyJournals of the American College of CardiologySafety and Effectiveness of Statins for Primary Prevention in Adults With Type 1 Diabetes: An Emulation  JAMA CardiologyOne-Year Outcomes of Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST ElevationAn Individual Patient Data Meta-Analysis Journal of Clinical Endocrinology & MetabolismAssociation Between Urinary Phthalate Metabolites and Sarcopenia in US Adults From NHANES 2011-2018 Diabetes careA Multimodal Predictive Model for Chronic Kidney Disease and Its Association With Vascular Complications in Patients With Type 2 Diabetes: Model Development and Validation Study in South Korea and the U.K.   NeurologyAssociation of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging  ChestInvestigating the Long-Term Effects of COVID-19 Infection on Health Care Utilization in Individuals With COPD The American Journal of Respiratory and Critical Care MedicineMolecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation Clinical Journal of American Society of NephrologySodium-Glucose Cotransporter 2 Inhibition and Hospitalizations in Patients with CKD: A Meta-Analysis of Kidney Outcome TrialsKidney International reportsProspective Pilot Study of Plasma Cell–Targeted Therapy With Bortezomib in Refractory IgA NephropathyCommunity-Acquired Acute Kidney Injury and Late Kidney Dysfunction in Survivors of COVID-19 Hospitalization