EPISODE · May 5, 2026 · 23 MIN
903-健康活体捐献者肝脏空间转录组图谱
from 聊聊Sci
这份研究通过对健康活体捐赠者进行空间转录组学和单细胞核测序，构建了首个人类肝脏空间基因表达图谱。研究发现，活体捐赠者的肝脏在基因表达上显著优于传统常用的死后捐赠或病灶旁组织，更能代表真实的健康基准。科学家揭示了人类肝脏特有的分区化特征，指出人类在代谢功能和免疫分布上与小鼠及其他哺乳动物存在重要差异。通过整合高分辨率影像与机器学习，该图谱还精准捕捉到了早期脂肪肝中肝细胞线粒体蛋白下降等动态病理变化。这一成果为理解肝脏生理功能及其在疾病早期的演变提供了关键的空间参考框架。References:Yakubovsky O, Bahar Halpern K, Shir S, et al. A spatial atlas of the healthy human liver from live donors[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
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903-健康活体捐献者肝脏空间转录组图谱
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