EPISODE · May 6, 2026 · 25 MIN
906-纹状体双记忆印迹调控酒精复吸与消退
from 聊聊Sci
这项研究揭示了大脑背侧纹状体中存在一种双重印迹架构，通过同一类神经元（dMSNs）的不同群体来分别调控酒精的复吸与消退。研究发现，酒精成瘾记忆由广泛分布在基质区的神经元集合编码，其活跃会驱动复吸行为；而消退训练则招募了富集在纹状小体的另一组神经元，起到抑制复吸的作用。这种功能差异源于皮层输入的突触强化：内侧前额叶皮层与复吸神经元之间的突触效能持久增强，构成了成瘾记忆的物理基础。科学家通过光遗传学手段模拟这种突触增强，成功在小鼠身上重建了类似酒精诱导的复吸行为。该发现不仅挑战了纹状体功能的传统认知，也为开发针对成瘾记忆的精准干预手段提供了关键的细胞与突触靶点。References:Xie X, Huang Y, Huang Z, et al. Dual Engram Architecture within a Single Striatal Cell Type Distinctly Controls Alcohol Relapse and Extinction[J]. bioRxiv, 2026: 2026.01. 13.699375.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
906-纹状体双记忆印迹调控酒精复吸与消退
0:00
25:44
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 25 minutes long.
When was this 聊聊Sci episode published?
This episode was published on May 6, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!