EPISODE · May 7, 2026 · 26 MIN
911-B细胞对肝脏谷氨酸代谢及运动能力的调节作用
from 聊聊Sci
这项研究揭示了B细胞在免疫反应之外，还发挥着通过肝-肌代谢轴调节身体运动能力的非免疫功能。研究发现，B细胞分泌的TGF-β1能够转录上调肝脏中的GLS2和SLC7A5，从而促进谷氨酰胺向谷氨酸的转化及其向外周的转运。这种由肝脏产生的谷氨酸在运动过程中会进入骨骼肌，进而激活钙信号通路并增强线粒体代谢功能。实验证明，B细胞缺失会导致循环谷氨酸水平下降，从而抑制肌肉性能并限制个体的运动耐力。相反，通过补充谷氨酸或恢复B细胞衍生的信号分子，可以有效逆转这种运动障碍。总之，该成果阐明了免疫系统如何跨器官协同代谢，以维持机体在高强度体力活动下的生理表现。References:Mao Y, Xia Z, Pan X, et al. B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism[J]. Cell, 2026.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
911-B细胞对肝脏谷氨酸代谢及运动能力的调节作用
0:00
26:12
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 26 minutes long.
When was this 聊聊Sci episode published?
This episode was published on May 7, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!