EPISODE · May 7, 2026 · 20 MIN
914-果蝇病原体回避的脑-脂肪体双向轴
from 聊聊Sci
这项研究揭示了果蝇体内一种双向的“脑-脂肪体轴”通讯机制，用以调控摄入病原体后的回避行为。当果蝇食入有害细菌时，其章鱼胺能神经元会通过免疫受体感知病原体，并刺激脂肪体释放多巴胺。这种源自脂肪体的多巴胺随后作用于大脑蘑菇体输出神经元中的受体，促使果蝇改变对细菌气味的偏好。研究强调了特定抗菌肽（如DptB）在这一过程中的关键作用，证实了免疫系统与代谢器官能直接干预神经环路。这一发现不仅展示了外周组织如何驱动行为适应，也为理解神经-免疫-代谢三方相互作用提供了进化上的新视角。References:Wang Y, De Backer J F, Muria A, et al. A bidirectional brain-fat body axis for pathogen avoidance[J]. Neuron, 2024.前往小宇宙评论区与主播互动
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914-果蝇病原体回避的脑-脂肪体双向轴
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