EPISODE · May 8, 2026 · 21 MIN
916-睡眠状态转变下星形胶质细胞体积的动态变化
from 聊聊Sci
这项研究通过体内双光子成像技术，揭示了小鼠大脑皮层星形胶质细胞体积在睡眠-觉醒周期中的动态变化。研究发现，星形胶质细胞在清醒状态下体积最大，在非快速眼动（NREM）睡眠中缩小，而在快速眼动（REM）睡眠中体积最小。这种体积波动与去甲肾上腺素（NE）的浓度变化高度同步，且主要由α1-肾上腺素能受体信号驱动。通过光遗传学和化学遗传学手段激活相关神经元，研究证实了去甲肾上腺素释放会引发细胞扩张。这种细胞体积的收缩与扩张会反向影响组织间隙分率，进而可能调节脑脊液的流体动力学及胶质淋巴系统的清除功能。这一发现为理解星形胶质细胞如何通过结构可塑性参与调节不同大脑功能状态提供了新视角。References:Deng S, Hu Y, Chen X, et al. Astrocyte cell volume dynamics across cortical states and transitions[J]. Neuron, 2026.前往小宇宙评论区与主播互动
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916-睡眠状态转变下星形胶质细胞体积的动态变化
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