EPISODE · May 8, 2026 · 21 MIN
917-双向胶质回路调控脑损伤反应平衡
from 聊聊Sci
这项研究揭示了一种由星形胶质细胞与小胶质细胞构成的相互作用回路，该回路在脑损伤后通过负反馈机制维持组织响应的平衡。实验发现，脑损伤会触发星形胶质细胞释放ATP信号（Inflares），其强度与损伤程度呈线性相关。作为响应，小胶质细胞会释放细胞因子 IL-1β，通过激活星形胶质细胞上的 IL-1R1 受体及钙离子-钙调磷酸酶通路，精确抑制过度的 ATP 释放。如果这一调节回路遭到破坏，会导致 ATP 信号失控，进而引发异常的免疫反应、阻碍神经网络修复并加剧早期组织损伤。该发现阐明了胶质细胞如何通过分子对话动态校准损伤信息，为治疗中枢神经系统损伤提供了全新的靶点思路。References:Luan P, Jia J, Chen Y, et al. A reciprocal glial circuit calibrates injury information and governs the tissue response balance[J]. Neuron, 2026.前往小宇宙评论区与主播互动
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917-双向胶质回路调控脑损伤反应平衡
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