EPISODE · May 8, 2026 · 20 MIN
919-抑制NMD途径重塑癌症免疫肽图谱
from 聊聊Sci
这项研究揭示了无义介导的 mRNA 降解（NMD）是肿瘤免疫逃逸的关键机制，它会清除含有提前终止密码子的转录本，从而使潜在的抗原变得“不可见”。通过抑制 NMD 路径中的核心激酶 SMG1，研究人员成功稳定了这些异常的 RNA，并诱导肿瘤细胞呈递出一类全新的非规范新抗原。实验证明，这种策略能显著增加肿瘤的抗原负载量，使其水平足以媲美高突变负荷的肿瘤。在患者来源的模型和动物实验中，NMD 抑制激活了肿瘤内原有的 T 细胞，并增强了免疫检查点阻断疗法的疗效。总之，该发现为提升癌症免疫治疗的广度提供了一种无需诱导 DNA 损伤的新型策略。References:Vendramin R, Fu H, Patel S F, et al. Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome[J]. Immunity, 2026.前往小宇宙评论区与主播互动
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919-抑制NMD途径重塑癌症免疫肽图谱
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