92: Mass Transfer Secrets: Mastering Bubbles and kLa from Bench to Large-Scale Production with Lars Puiman & Rik Volger - Part 2

Ever wondered why your perfectly optimized lab process falls apart at industrial scale?Mass transfer experts Lars Puiman and Rik Volger from the University of Delft reveal the hidden world of oxygen transfer and aeration that can make or break your production.Dive into the crucial differences between lab-scale and industrial-scale bioreactors, and discover why your DO sensor might be fooling you. Learn how CFD simulations and innovative downscaling techniques can revolutionize your scale-up strategy.In this episode, you'll gain:Insider tips for predicting and managing concentration gradients in large-scale reactorsCutting-edge methods to measure kLa accurately in industrial settingsStrategies to leverage microfluidics for cost-effective process developmentFrom the basics of bubble behavior to the latest in AI and machine learning, this episode is packed with practical insights to enhance your bioprocess efficiency and product quality. Don't miss out on these game-changing mass transfer secrets – tune in now and take your bioprocessing skills to the next level!Connect with our guests:Lars Puiman: https://www.linkedin.com/in/larspuimanRik Volger:  https://www.linkedin.com/in/rikvolgerNext Step:Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentAdditional Resources:Bubbles and Broth: A review on the impact of broth composition on bubble column bioreactor hydrodynamicsRead the review paper at https://doi.org/10.1016/j.bej.2023.109124Support the show