EPISODE · May 8, 2026 · 21 MIN
927-人脑血脑屏障发育的时空转录组解码
from 聊聊Sci
这份研究通过单细胞转录组学与空间转录组技术，系统地描绘了人类血脑屏障在发育过程中的时空演变特征。研究团队确立了人类血脑屏障特异性转录特征起始于妊娠第8周，并揭示了神经细胞通过CDH2信号通路诱导内皮细胞表达关键转运蛋白。此外，研究发现神经祖细胞能分泌PDGFD来促进壁细胞的增殖，进一步完善了神经血管单元的相互作用网络。通过跨物种比较，该研究证实了人类与小鼠在血脑屏障发育上的进化保守性。最后，实验证明了H2A.Z.1蛋白在调控血管生成及维持血脑屏障功能稳定性中发挥着至关重要的作用。这些成果为理解人类大脑稳态的建立以及相关疾病的治疗靶点提供了重要依据。References:Li Z, Li Y, He Z, et al. Decoding the spatiotemporal development of the blood-brain barrier in human cortex[J]. Cell Stem Cell, 2026.前往小宇宙评论区与主播互动
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927-人脑血脑屏障发育的时空转录组解码
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