EPISODE · May 8, 2026 · 20 MIN
933-衰老诱导的小鼠白质微循环引流障碍与脱髓鞘研究
from 聊聊Sci
这篇研究通过深度多光子成像技术，揭示了小鼠白质退化与微血管引流障碍之间的因果关系。研究人员首次在小鼠大脑深层发现了与人类结构相似的主皮层静脉，该静脉是深层组织唯一的血液出口。实验表明，老龄化会导致这些静脉分支末端的毛细血管发生萎缩与稀疏化，进而引发轻度慢性缺血。这种特定的血流动力学改变直接触发了皮层第六层及胼胝体中的胶质增生和脱髓鞘病变。该成果证明了毛细血管-静脉引流受损是导致大脑白质衰老的核心因素，为预防老年认知减退提供了新的治疗靶点。References:Stamenkovic S, Schmid F, Gurler G, et al. Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging[J]. Nature Neuroscience, 2025, 28(9): 1868-1882.前往小宇宙评论区与主播互动
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933-衰老诱导的小鼠白质微循环引流障碍与脱髓鞘研究
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